Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210/ISCU Axis Activation.
Identifieur interne : 000079 ( Main/Exploration ); précédent : 000078; suivant : 000080Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210/ISCU Axis Activation.
Auteurs : Mindi He [République populaire de Chine] ; Chao Zhou [République populaire de Chine] ; Yonghui Lu [République populaire de Chine] ; Ling Mao [République populaire de Chine] ; Yu Xi [République populaire de Chine] ; Xiang Mei [République populaire de Chine] ; Xue Wang [République populaire de Chine] ; Lei Zhang [République populaire de Chine] ; Zhengping Yu [République populaire de Chine] ; Zhou Zhou [République populaire de Chine]Source :
- Oxidative medicine and cellular longevity [ 1942-0994 ] ; 2020.
Abstract
Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1α (HIF-1α). Melatonin has shown diverse anticancer properties for its reactive oxygen species- (ROS-) scavenging ability. Our aim was to explore how melatonin antagonized a nickel-induced increment in aerobic glycolysis. In the current work, a normal human bronchial epithelium cell line (BEAS-2B) was exposed to a series of nonlethal doses of NiCl2, with or without 1 mM melatonin. Melatonin attenuated nickel-enhanced aerobic glycolysis. The inhibition effects on aerobic glycolysis were attributed to the capability of melatonin to suppress the regulatory axis comprising HIF-1α, microRNA210 (miR210), and iron-sulfur cluster assembly scaffold protein (ISCU1/2). N-Acetylcysteine (NAC) manifested similar effects as melatonin in scavenging ROS, maintaining prolyl-hydroxylase activity, and mitigating HIF-1α transcriptional activity in nickel-exposed cells. Our results indicated that ROS generation contributed to nickel-caused HIF-1α stabilization and downstream signal activation. Melatonin could antagonize HIF-1α-controlled aerobic glycolysis through ROS scavenging.
DOI: 10.1155/2020/5406284
PubMed: 32566089
PubMed Central: PMC7275958
Affiliations:
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wicri:level="1"><nlm:affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Occupational Health, Army Medical University, 400038 Chongqing</wicri:regionArea><wicri:noRegion>400038 Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Yonghui" sort="Lu, Yonghui" uniqKey="Lu Y" first="Yonghui" last="Lu">Yonghui Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Occupational Health, Army Medical University, 400038 Chongqing</wicri:regionArea><wicri:noRegion>400038 Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Ling" sort="Mao, Ling" uniqKey="Mao L" first="Ling" last="Mao">Ling Mao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Occupational Health, Army Medical University, 400038 Chongqing</wicri:regionArea><wicri:noRegion>400038 Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Xi, Yu" sort="Xi, Yu" uniqKey="Xi Y" first="Yu" last="Xi">Yu Xi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Environmental Medicine, School of Public Health, and Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, 310058 Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Environmental Medicine, School of Public Health, and Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, 310058 Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Mei, Xiang" sort="Mei, Xiang" uniqKey="Mei X" first="Xiang" last="Mei">Xiang Mei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Occupational Health, Army Medical University, 400038 Chongqing</wicri:regionArea><wicri:noRegion>400038 Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Xue" sort="Wang, Xue" uniqKey="Wang X" first="Xue" last="Wang">Xue Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Occupational Health, Army Medical University, 400038 Chongqing</wicri:regionArea><wicri:noRegion>400038 Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Occupational Health, Army Medical University, 400038 Chongqing</wicri:regionArea><wicri:noRegion>400038 Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Zhengping" sort="Yu, Zhengping" uniqKey="Yu Z" first="Zhengping" last="Yu">Zhengping Yu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Occupational Health, Army Medical University, 400038 Chongqing</wicri:regionArea><wicri:noRegion>400038 Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Zhou" sort="Zhou, Zhou" uniqKey="Zhou Z" first="Zhou" last="Zhou">Zhou Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Occupational Health, Army Medical University, 400038 Chongqing</wicri:regionArea><wicri:noRegion>400038 Chongqing</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Environmental Medicine, School of Public Health, and Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, 310058 Hangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Environmental Medicine, School of Public Health, and Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, 310058 Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><series><title level="j">Oxidative medicine and cellular longevity</title><idno type="eISSN">1942-0994</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1<i>α</i> (HIF-1<i>α</i>). Melatonin has shown diverse anticancer properties for its reactive oxygen species- (ROS-) scavenging ability. Our aim was to explore how melatonin antagonized a nickel-induced increment in aerobic glycolysis. In the current work, a normal human bronchial epithelium cell line (BEAS-2B) was exposed to a series of nonlethal doses of NiCl<sub>2</sub>, with or without 1 mM melatonin. Melatonin attenuated nickel-enhanced aerobic glycolysis. The inhibition effects on aerobic glycolysis were attributed to the capability of melatonin to suppress the regulatory axis comprising HIF-1<i>α</i>, microRNA210 (miR210), and iron-sulfur cluster assembly scaffold protein (ISCU1/2). N-Acetylcysteine (NAC) manifested similar effects as melatonin in scavenging ROS, maintaining prolyl-hydroxylase activity, and mitigating HIF-1<i>α</i> transcriptional activity in nickel-exposed cells. Our results indicated that ROS generation contributed to nickel-caused HIF-1<i>α</i> stabilization and downstream signal activation. Melatonin could antagonize HIF-1<i>α</i>-controlled aerobic glycolysis through ROS scavenging.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32566089</PMID><DateRevised><Year>2020</Year><Month>06</Month><Day>23</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1942-0994</ISSN><JournalIssue CitedMedium="Internet"><Volume>2020</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Oxidative medicine and cellular longevity</Title><ISOAbbreviation>Oxid Med Cell Longev</ISOAbbreviation></Journal><ArticleTitle>Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1<i>α</i>/miR210/ISCU Axis Activation.</ArticleTitle><Pagination><MedlinePgn>5406284</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2020/5406284</ELocationID><Abstract><AbstractText>Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1<i>α</i> (HIF-1<i>α</i>). Melatonin has shown diverse anticancer properties for its reactive oxygen species- (ROS-) scavenging ability. Our aim was to explore how melatonin antagonized a nickel-induced increment in aerobic glycolysis. In the current work, a normal human bronchial epithelium cell line (BEAS-2B) was exposed to a series of nonlethal doses of NiCl<sub>2</sub>, with or without 1 mM melatonin. Melatonin attenuated nickel-enhanced aerobic glycolysis. The inhibition effects on aerobic glycolysis were attributed to the capability of melatonin to suppress the regulatory axis comprising HIF-1<i>α</i>, microRNA210 (miR210), and iron-sulfur cluster assembly scaffold protein (ISCU1/2). N-Acetylcysteine (NAC) manifested similar effects as melatonin in scavenging ROS, maintaining prolyl-hydroxylase activity, and mitigating HIF-1<i>α</i> transcriptional activity in nickel-exposed cells. Our results indicated that ROS generation contributed to nickel-caused HIF-1<i>α</i> stabilization and downstream signal activation. Melatonin could antagonize HIF-1<i>α</i>-controlled aerobic glycolysis through ROS scavenging.</AbstractText><CopyrightInformation>Copyright © 2020 Mindi He et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>He</LastName><ForeName>Mindi</ForeName><Initials>M</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1179-4099</Identifier><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Chao</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Yonghui</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mao</LastName><ForeName>Ling</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xi</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Environmental Medicine, School of Public Health, and Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, 310058 Hangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mei</LastName><ForeName>Xiang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xue</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Zhengping</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Zhou</ForeName><Initials>Z</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-5501-5208</Identifier><AffiliationInfo><Affiliation>Department of Occupational Health, Army Medical University, 400038 Chongqing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Environmental Medicine, School of Public Health, and Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, 310058 Hangzhou, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Oxid Med Cell Longev</MedlineTA><NlmUniqueID>101479826</NlmUniqueID><ISSNLinking>1942-0994</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CoiStatement>The authors declare that no conflict of interest exists.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate 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last="Mao">Ling Mao</name><name sortKey="Mei, Xiang" sort="Mei, Xiang" uniqKey="Mei X" first="Xiang" last="Mei">Xiang Mei</name><name sortKey="Wang, Xue" sort="Wang, Xue" uniqKey="Wang X" first="Xue" last="Wang">Xue Wang</name><name sortKey="Xi, Yu" sort="Xi, Yu" uniqKey="Xi Y" first="Yu" last="Xi">Yu Xi</name><name sortKey="Yu, Zhengping" sort="Yu, Zhengping" uniqKey="Yu Z" first="Zhengping" last="Yu">Zhengping Yu</name><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name><name sortKey="Zhou, Chao" sort="Zhou, Chao" uniqKey="Zhou C" first="Chao" last="Zhou">Chao Zhou</name><name sortKey="Zhou, Zhou" sort="Zhou, Zhou" uniqKey="Zhou Z" first="Zhou" last="Zhou">Zhou Zhou</name><name sortKey="Zhou, Zhou" sort="Zhou, Zhou" uniqKey="Zhou Z" first="Zhou" last="Zhou">Zhou Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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